Proloterapia en la gonartrosis

Alejandro Alvarez López, Rodrigo Fuentes-Véjar, Sergio Ricardo Soto-Carrasco, Yenima de la Caridad García Lorenzo

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Resumen

Fundamento: la gonartrosis es una entidad muy frecuente y afecta a un grupo numeroso de pacientes en especial a los mayores de 40 años. El tratamiento conservador constituye la primera línea e incluye la proloterapia.
Objetivo:
actualizar los conocimientos en relación al uso de la proloterapia en pacientes con gonartrosis.
Métodos: la búsqueda y análisis de la información se realizó en un periodo de dos meses (primero de febrero de 2020 al 30 de abril de 2020) y se emplearon las siguientes palabras: prolotherapy, regenerative injection therapy and chronic musculoskeletal pain. A partir de la información obtenida se realizó una revisión bibliográfica de un total de 203 artículos publicados en las bases de datos PubMed, Hinari, SciELO y Medline mediante el gestor de búsqueda y administrador de referencias EndNote, de ellos se utilizaron 39 citas seleccionadas para realizar la revisión, de ellas 32 de los últimos cinco años, además se consultó un libro.
Resultados: se mencionan las concentraciones a emplear tanto intra como periarticular, indicaciones y mecanismos de acción. Se describen la frecuencia de su aplicación, así como la comparación con otros métodos de tratamiento por vía intraarticular. Se hace referencia a la duración de su efecto y complicaciones.
Conclusiones: la proloterapia mediante la administración de dextrosa hipertónica intrarticular es un método útil en el tratamiento de pacientes con gonartrosis, su fácil aplicación, disponibilidad y bajo índice de complicaciones lo convierten en un método conservador factible y efectivo.

Palabras clave

proloterapia; gonartrosis; osteoartritis de la rodilla; tratamiento conservador

Referencias

Vigorita VJ. Orthopaedic Pathology. 3 rd ed. Philadelphia: Wolters Kluwer; 2016.

Arias-Vázquez PI, Tovilla-Zárate CA, Legorreta-Ramírez BG, Burad Fonz W, Magaña-Ricardez D, González-Castro TB, et al. Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials. Adv Rheumatol. 2019 Aug;59(1):39.

Cianca JC, Jayaram P. Musculoskeletal injuries and regenerative medicine in the elderly patient. Phys Med Rehabil Clin N Am. 2017 Nov;28(4):777-94.

Hosseini B, Taheri M, Pourroustaei Ardekani R, Moradi S, Kazempour Mofrad M. Periarticular hypertonic dextrose vs intraarticular hyaluronic acid injections: a comparison of two minimally invasive techniques in the treatment of symptomatic knee osteoarthritis. Open Access Rheumatol. 2019 Nov;11:269-74.

Reeves KD, Sit RW, Rabago DP. Dextrose prolotherapy: a narrative review of basic science, clinical research, and best treatment recommendations. Phys Med Rehabil Clin N Am. 2016 Nov;27(4):783-823.

Singh V, Trescot A, Nishio I. Injections for chronic pain. Phys Med Rehabil Clin N Am. 2015 May;26(2):249-61.

Rezasoltani Z, Taheri M, Mofrad MK, Mohajerani SA. Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res. 2017 May;10:1179-87.

Chen SH, Kuan TS, Kao MJ, Wu WT, Chou LW. Clinical effectiveness in severe knee osteoarthritis after intra-articular platelet-rich plasma therapy in association with hyaluronic acid injection: three case reports. Clin Interv Aging. 2016 Sep;11:1213-9.

Sit RW, Chung VCh, Reeves KD, Rabago D, Chan KK, Chan DC, et al. Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: a systematic review and meta-analysis. Sci Rep. 2016 May;6:25247.

Sit RWS, Wu RWK, Reeves KD, Rabago D, Chan DCC, Yip BHK, et al. Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial. BMC Complement Altern Med. 2018 May;18(1):157.

Krsticevic M, Jeric M, Došenovic S, Jelicic Kadic A, Puljak L. Proliferative injection therapy for osteoarthritis: a systematic review. Int Orthop. 2017 Apr;41(4):671-9.

Tieppo Francio V, Dima RS, Towery C, Davani S. Prolotherapy and low level laser therapy: a synergistic approach to pain management in chronic osteoarthritis. Anesth Pain Med. 2017 Oct;7(5):e14470.

Hauser RA, Lackner JB, Steilen-Matias D, Harris DK. A systematic review of dextrose prolotherapy for chronic musculoskeletal pain. Clin Med Insights Arthritis Musculoskelet Disord. 2016 Jul;9:139-59.

Hassan F, Murrell WD, Refalo A, Maffulli N. Alternatives to biologics in management of knee osteoarthritis: a systematic review. Sports Med Arthrosc Rev. 2018 Jun;26(2):79-85.

Covey CJ, Sineath MH Jr, Penta JF, Leggit JC. Prolotherapy: can it help your patient? J Fam Pract. 2015 Dec;64(12):763-8.

Isik R, Karapolat H, Bayram KB, Usan H, Tanigör G, Atamaz Çalis F. Effects of short wave diathermy added on dextrose prolotherapy injections in osteoarthritis of the knee. J Altern Complement Med. 2020 Apr;26(4):316-22.

Poddar SK, Widstrom L. Nonoperative options for management of articular cartilage disease. Clin Sports Med. 2017 Jul;36(3):447-56.

Farpour HR, Fereydooni F. Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: a randomized clinical trial. Electron Physician. 2017 Nov;9(11):5663-9.

Hulsopple C. Musculoskeletal therapies: musculoskeletal injection therapy. FP Essent. 2018 Jul;470:21-6.

Russell SJ, Sala R, Conaghan PG, Habib G, Vo Q, Manning R, et al. Triamcinolone acetonide extended-release in patients with osteoarthritis and type 2 diabetes: a randomized, phase 2 study. Rheumatology (Oxford). 2018 Dec;57(12):2235-41.

Eslamian F, Amouzandeh B. Therapeutic effects of prolotherapy with intra-articular dextrose injection in patients with moderate knee osteoarthritis: a single-arm study with 6 months follow up. Ther Adv Musculoskelet Dis. 2015 Apr;7(2):35-44.

Sert AT, Ozcan E, Esmaeilzadeh S. Poster 383 effects of dextrose prolotherapy in the treatment of patients with knee osteoarthritis: a randomized controlled trial. PM R. 2016 Sep;8(9S):S286.

Shan Sit RW, Keung Wu RW, Rabago D, Reeves KD, Chun Chan DC, Kei Yip BH, et al. Efficacy of intra-articular hypertonic dextrose (prolotherapy) for knee osteoarthritis: a randomized controlled trial. Ann Fam Med. 2020 May;18(3):235-42.

Driban JB, Eaton CB, Amin M, Stout AC, Price LL, Lu B, et al. Glucose homeostasis influences the risk of incident knee osteoarthritis: data from the osteoarthritis initiative. J Orthop Res. 2017 Oct;35(10):2282-7.

Sert AT, Sen EI, Esmaeilzadeh S, Ozcan E. The effects of dextrose prolotherapy in symptomatic knee osteoarthritis: a randomized controlled study. J Altern Complement Med. 2020 May;26(5):409-17.

Hung CY, Hsiao MY, Chang KV, Han DS, Wang TG. Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis. J Pain Res. 2016 Oct;9:847-57.

Rabago D, Nourani B. Prolotherapy for osteoarthritis and tendinopathy: a descriptive review. Curr Rheumatol Rep. 2017 Jun;19(6):34.

Hassan F, Trebinjac S, Murrell WD, Maffulli N. The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review. Br Med Bull. 2017 Jun;122(1):91-108.

Rabago D, Reeves KD, Doherty MP, Fleck M. Prolotherapy for musculoskeletal pain and disability in low- and middle-income countries. Phys Med Rehabil Clin N Am. 2019 Nov;30(4):775-786.

Topol GA, Podesta LA, Reeves KD, Giraldo MM, Johnson LL, Grasso R, et al. Chondrogenic effect of intra-articular hypertonic-dextrose (Prolotherapy) in severe knee osteoarthritis. PM R. 2016 Nov;8(11):1072-82.

Rabago D, van Leuven L, Benes L, Fortney L, Slattengren A, Grettie J, et al. Qualitative assessment of patients receiving prolotherapy for knee osteoarthritis in a multimethod study. J Altern Complement Med. 2016 Dec;22(12):983-9.

Rabago D, Kansariwala I, Marshall D, Nourani B, Stiffler-Joachim M, Heiderscheit B. Dextrose prolotherapy for symptomatic knee osteoarthritis: feasibility, acceptability, and patient-oriented outcomes in a pilot-level quality improvement project. J Altern Complement Med. 2019 Apr;25(4):406-12.

Reeves KD, Hassanein K. Randomized prospective double blind placebo controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med. 2000 Mar;6(2)68-74.

Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA, et al. Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. Ann Fam Med. 2013 May-Jun; 11(3):229-37.

Rabago D, Kijowski R, Woods M, Patterson JJ, Mundt M, Zgierska A, et al. Association between disease-specific quality of life and magnetic resonance imaging outcomes in a clinical trial of prolotherapy for knee osteoarthritis. Arch Phys Med Rehabil. 2013 Nov;94(11):2075-82.

Hashemi SM, Madadi F, Razavi S, Nikooseresht M, Kibabi FH, Nasiripour S. Intra-articular hyaluronic acid injections vs dextrose prolotherapy in the treatment of osteoarthritic knee pain. Tehran University Med J. 2012 Feb;70(2):119-25.

Hashemi M, Jalili P, Mennati S, Koosha A, Rohanifar R, Madadi F, et al. The effects of prolotherapy with hypertonic dextrose versus prolozone (intraarticular Ozone) in patients with knee osteoarthritis. Anesth Pain Med. 2015 Oct;5(5):e27585.

Rahimzadeh P, Imani F, Faiz SHR, Entezary SR, Zamanabadi MN, Alebouyeh MR. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clin Interv Aging. 2018 Jan;13:73-79.

Rahimzadeh P, Imani F, Faiz SH, Entezary SR, Nasiri AA, Ziaeefard M. Investigation the efficacy of intra-articular prolotherapy with erythropoietin and dextrose and intra-articular pulsed radiofrequency on pain level reduction and range of motion improvement in primary osteoarthritis of knee. J Res Med Sci. 2014 Aug;19(8):696-702.

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