El FRAX como herramienta para evaluar el riesgo de fracturas en población general y grupos especiales de riesgo

Gil Alberto Reyes Llerena, Zoila Marlene Guibert Toledano, Gil Reyes Guibert, José Martínez Quezada, Evelia Molinet Fuertes, Dennis Carrillo Lovet, Rafael Frías Pita

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Resumen

El  FRAX  es una herramienta que  cuenta con un algoritmo computarizado desarrollado por la Organización Mundial de la Salud, basado en modelos globales de cohortes de población, combinados con factores de riesgo clínico, que mide el riesgo de fractura. La herramienta fue diseñada  inicialmente para  su aplicación por los médicos de atención primaria en mujeres post-menopáusicas y hombres sobre 50 años, aunque es válida en general entre 40-90 años. Es la herramienta más utilizada  en pacientes con baja densidad mineral ósea en caderas, también para medir riesgo a diez años de fractura ósea mayor osteoporótica a diferentes niveles de la anatomía.  La herramienta de medición utilizada para medir la densidad mineral ósea  son los estudios DEXA.

Palabras clave

FRAX; osteoporosis; fracturas por osteoporosis

Referencias

Kanis JA, Harvey NC, Johansson H, Odén A, Leslie WD, McCloskey EV. FRAX and fracture prediction without bone mineral density. Climacteric [Internet]. 2015 [citado 12 Sep 2020];18(Sup2):2-9. Disponible en: https://www.tandfonline.com/doi/abs/10.3109/13697137.2015.1092342

Chao AS, Chen FP, Lin YC, Huang TS, Fan CM, Yu YW. Application of the World Health Organization Fracture Risk Assessment Tool to predict need for dual-energy X-ray absorptiometry scanning in postmenopausal women. Taiwan J Obstet Gynecol [Internet]. 2015 Dec [citado 12 Sep 2020];54(6):722-5. Disponible en: https://www.sciencedirect.com/science/article/pii/S1028455915002363

Masud T, Binkley N, Boonen S, Hannan MT, Members FPDC. Official Positions for FRAX(R) clinical regarding falls and frailty: can falls and frailty be used in FRAX(R)? From Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX(R). J Clinical Densitometry [Internet]. 2011 [citado 12 Sep 2020];14(3):194-204. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1094695011001223

European AIDS Clinical Society (EACS). Guidelines. Version 8, October 2015. [Internet]. [actualizado: 2018; citado 12 Sep 2020]. Disponible en: http://www.eacsociety.org/files/2-english_rev-20151221.pdf

Reyes LLerena Gil A, Guibert Toledano M, Millán Marcelo JC. Manifestaciones reumáticas en la epidemia VIH-SIDA en la era previa a la terapia antirretroviral sumamente activa en Cuba. Una puesta al día. Rev Peruana de Reumatología. 2016;(22):25-33.

Reyes Llerena GA, Guibert Toledano M, Penedo Coello A, Pérez Rodríguez A, Baez Dueñas RM, Charnicharo Vidal R. Community study based to estimate the prevalence and burden of illness of rheumatic diseases in Cuba. A COPCORD study. J Clin Rheumatol [Internet]. 2009 [citado 12 Sep 2020];15(2):51-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19265344/

Kanis JA, Odén A, Johnell O, Johansson H, De Laet C, Brown J, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int [Internet]. 2007 [citado 12 Sep 2020];18(8):1033•46. Disponible en: https://link.springer.com/article/10.1007/s00198-007-0343-y

Yin MT, Skanderson M, Shiau S, et al. Fracture prediction with modified FRAX in older HIV+ and HIV• men. Conference of Retroviruses and Opportunistic Infections. Seattle: CROI; 2015. [Internet] [citado 12 Sep 2020]. Disponible en: https://www.croiconference.org/abstract/fracture-prediction-modified-frax-older-hiv-and-hiv-men/

Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, et al. Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey). Endocr J [Internet]. 2018 [citado 12 Sep 2020];65(2):193-202. Disponible en: https://www.jstage.jst.go.jp/article/endocrj/65/2/65_EJ17-0331/_article/-char/ja/

Kanis JA, Johnell O, Odén A, Johansson H, McCloskey E. FRAXTM and the assessment of fracture probability in men and women from the UK. Osteoporos Int [Internet]. 2008 [citado 12 Sep 2020];19:385-97. Disponible en: https://link.springer.com/article/10.1007/s00198-007-0543-5

Fujiwara S, Kasagi F, Masunari N, Naito K, Suzuki G. Fukunaga M. Fracture prediction from bone mineral density in Japanese men and women. Journal of Bone and Mineral Research. 2003;18(8):1547-53.

Lundgren JD, Battegay M, Behrens G, De Wit S, Guaraldi G, Katlama C, et al. European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV. HIV Med [Internet]. 2008 [citado 12 Sep 2020];9(2):72-81.

Kim BY, Kim HA, Jung JY, Choi ST, Kim JM, Kim SH, et al. Impact of the Fracture Risk Assessment Tool on the Treatment Decision for Osteoporosis in Patients with Knee Osteoarthritis: A Multicenter Comparative Study of the Fracture Risk Assessment Tool and World Health Organization Criteria. J Clin Med [Internet]. 2019 [citado 12 Sep 2020];8(7):E918. Disponible en: https://www.mdpi.com/2077-0383/8/7/918

Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporosis international [Internet]. 2013 [citado 12 Sep 2020];24(1):23-57. Disponible en: https://link.springer.com/article/10.1007/s00198-012-2074-y

Kanis JA, on behalf OF the World Health Organization Scientific Group. Assessment of osteoporosis at the primary health-care level. Technical Report. WHO Collaborating Centre, University of Sheffield, UK; 2008. [Internet] [citado 12 Sep 2020] Disponible en: https://www.sheffield.ac.uk/FRAX/pdfs/WHO_Technical_Report.pdf

Neuprez A, Johansson H, Kanis JA, McCloskey EV, Odén A, Bruyère O, et al. Rationalisation du remboursement des me ´dicamentsde l•oste´oporose: de la mesure isole ´e de la densite ´ osseuse a ` l•inte ´gration des facteurscliniques de risque fracturaire. Validation de l•algorithme FRAX. Rev Med Liege [Internet]. 2009 [citado 12 Sep 2020];64(12):612-9. Disponible en: https://orbi.uliege.be/bitstream/2268/80892/1/Rationalisation%20du%20Remboursement%20des%20m%c3%a9dicaments%20de%20l%27ost%c3%a9oporose...pdf

Bastos-Silva Y, Aguiar LB, Pinto-Neto AM, Baccaro LF, Costa-Paiva L. Correlation between osteoporotic fracture risk in Brazilian postmenopausal women calculated using the FRAX with and without the inclusion of bone densitometry data. Arch Osteoporos [Internet]. 2016 [citado 12 Sep 2020];11(1):16. Disponible en: https://link.springer.com/article/10.1007/s11657-015-0255-y

Sociedad Cubana de Endocrinología, Sociedad Cubana de Reumatología. Guías nacionales para el diagnóstico y tratamiento de la Osteoporosis. Soc. Cubana de Endocrinología. Soc. Cubana de Reumatología. Rev Cubana Endocrinol [Internet]. 2014 [citado 12 Jun 2018];25(1):1-34. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532014000100001

Haugeberg G, Ørstavik RE, Kvien TK. Effects of rheumatoid arthritis on bone. Curr Opin Rheumatol [Internet]. 2003 [citado 12 Sep 2020];15(4):469-75. Disponible en: https://journals.lww.com/co-rheumatology/Fulltext/2003/07000/Effects_of_rheumatoid_arthritis_on_bone.16.aspx?casa_token=FVeEt_Lx52UAAAAA:h5WHqy-pa4g0bXFGWJQv5OxOd1prg0l9UQrC44Ddz0ui_HZUOYm43_QUEca7o1Utth4sGqh2uXhNxfdx8nQ3nna4mWqvk4E

Rossini M, Viapiana O, Adami S, Fracassi E, Idolazzi L, Dartizio C, et al. In patients with rheumatoid arthritis, Dickkopf-1 serum levels are correlated with parathyroid hormone, bone erosions and bone mineral density. Clin Exp Rheumatol [Internet]. 2015 [citado 10 Oct 2020];33(1):77-83. Disponible en: https://www.clinexprheumatol.org/article.asp?a=7389

Rossini M, Bagnato G, Frediani B, Iagnocco A, La montagna G, Minisola G, et al. Relationship of focal erosions, bone mineral density, and parathyroid hormone in rheumatoid arthritis. J Rheumatol [Internet]. 2011 [citado 12 Sep 2020];38(6):997-1002. Disponible en: https://www.jrheum.org/content/38/6/997.short

Phuan-udo R, Lektrakul M, Katchamart W. The association between 10-year fracture risk by FRAX and osteoporotic fractures with disease activity in patients with rheumatoid arthritis. Clinical Rheumatology [Internet]. 2018 [citado 10 Oct 2020];37(10):2603-10. Disponible en: https://link.springer.com/article/10.1007/s10067-018-4218-8

Raterman HG, Lems WF. Pharmacological management of osteoporosis in rheumatoid arthritis patients: a review of the literature and practical guide. Drugs & Aging [Internet]. 2019 [citado 12 Sep 2020];36(2):1061-72. Disponible en: https://link.springer.com/article/10.1007/s40266-019-00714-4

Grossman JM, Gordon R, Ranganath VK, Deal C, Caplan L, Chen W, et al. American College of Rheumatology 2010 recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Care Res (Hoboken) [Internet]. 2010 [citado 12 Sep 2020];62(11):1515-26. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/acr.20295

Angeli A, Guglielmi G, Dovio A, Capelli G, de Feo D, Giannini S, et al. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid Therapy: a cross-sectional outpatient study. Bone [Internet]. 2006 [citado 12 Sep 2020];39(2):253-9. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S8756328206002626

Kanis JA, Hans D, Cooper C, Baim S, Bilezikian JP, Binkley N, et al. Interpretation and use of FRAX in clinical practice. Osteoporos Int [Internet]. 2011 [citado 12 Sep 2020];22(9):2395. Disponible en: https://link.springer.com/article/10.1007/s00198-011-1713-z

Ye B, Huang YH, Zhang L, Tian XL, Zhang Q, Lu MH, et al. Clinical analysis of FRAX in the assessment of fracture risk in patients with rheumatic disease in three medical center. Zhonghua Yi Xue Za Zhi [Internet]. 2019 [citado 10 Oct 2020];99(42):3345-9. Disponible en: https://europepmc.org/article/med/31715673

Siris ES, Baim S, Nattiv A. Primary care use of FRAX®: absolute fracture risk assessment in postmenopausal women and older men. Postgrad Med [Internet]. 2010 Jan [citado 10 Oct 2020];122(1):82-90. Disponible en: https://europepmc.org/article/med/31715673

Kanis JA, Cooper C, Rizzoli R, Reginster JY. Executive summary of the European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Calcified tissue international. 2019;104(3):235-8.

Blake GM, Fogelman I. An update on dual-energy x-ray absorptiometry. In Seminars in nuclear medicine. 2010;40(1):62-73

Briot K, Cortet B, Thomas T, Audran M, Blain H, Breuil V, et al. 2012 update of French guidelines for the pharmacological treatment of postmenopausal osteoporosis. Joint Bone Spine [Internet]. 2012 [citado 12 Sep 2020];79(3):304-13. Disponible en: https://www.sciencedirect.com/science/article/pii/S1297319X1200053X

Nogués X, Nolla JM, Casado E, Jódar E, Muñoz-Torres M, Quesada-Gómez JM, et al. Spanish consensus on treat to target for osteoporosis. Osteoporosis Int [Internet]. 2018 [citado 12 Sep 2020];29:489-99. Disponible en: https://link.springer.com/article/10.1007/s00198-017-4310-y

Bodmer NS, Häuselmann HJ, Frey D, Aeberli D, Bachmann LM. Expert consensus on relevant risk predictors for the occurrence of osteoporotic fractures in specific clinical subgroups – Delphi survey. BMC Rheumatology [Internet]. 2019 [citado 12 Sep 2020]; 3(50):[aprox. 11 p.]. Disponible en: https://bmcrheumatol.biomedcentral.com/articles/10.1186/s41927-019-0099-y

Chen JF, Yu SF, Hsu CY, Chiu WC, Wu CH, Lai HM, et al. The role of bone mineral density in therapeutic decision-making using the Fracture Risk Assessment Tool (FRAX): a sub-study of the Taiwan Osteoporosis Survey (TOPS). Arch Osteoporos [Internet]. 2019 [citado 10 Oct 2020];14(1):101. Disponible en: https://link.springer.com/article/10.1007/s11657-019-0653-7

Schacter GI, Leslie WD. Based Measurements in Diabetes: Can They Predict Fracture Risk? Calcif Tissue Int [Internet]. 2017 [citado 10 Oct 2020];100(2):150-64. Disponible en: https://link.springer.com/article/10.1007%2Fs00223-016-0191-x

Bonaccorsi G, Messina C, Cervellati C, Maietti E, Medini M, Rossini M, et al. Fracture risk assessment in postmenopausal women with diabetes: comparison between De FRA and FRAX tools. Gynecol Endocrinol [Internet]. 2018 [citado 10 Oct 2020];34(5):404-8. Disponible en: https://www.tandfonline.com/doi/abs/10.1080/09513590.2017.1407308

Sessa A, Esposito A, Iavicoli GD, Lettieri E, Dente G, Costa C, et al. Immunosuppressive agents and bone disease in renal transplant patients with hypercalcemia. Trasplant Proc [Internet]. 2010 [citado 12 Sep 2020];42(4):1148-55. Disonible en: https://www.sciencedirect.com/science/article/abs/pii/S004113451000357X

Ban TH, Kim JH, Jang HB, Lee YS, Choi BS, Park CW, et al. Clinical effects of pre-transplant serum 25-hydroxyvitamin D level on post-transplant immunologic and non-immunologic outcomes in kidney transplant recipients). Trasplant Inmunol [Internet]. 2017 [citado 12 Sep 2020];40:51-6. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0966327416301599

Kalantar-Zadeh K, Molnar MZ, Kovesdy CP, Mucsi I, Bunnapradist S. Management of mineral and bone disorder after kidney transplantation. Curr Opin Nephrol Hypertensi [Internet]. 2012 [citado 12 Sep 2020];21(4):389-403. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532932/

Wang J, Yao M, Xu JH, Shu B, Wang YJ, Cui XJ. Bisphosphonates for prevention of osteopenia in kidney-transplant recipients: a systematic review of randomized controlled trials. Osteop Int [Internet]. 2016 [citado 12 Sep 2020];27(5):1683-90. Disponible en: https://link.springer.com/article/10.1007%2Fs00198-015-3465-7

Pundole X, Murphy WA, Ebede CC, Karim E, Manocha S, Don-Pedro D, et al. Fracture risk prediction using FRAX in patients following hematopoietic stem cell transplantation. Arch Osteoporos [Internet]. 2018 [citado 12 Sep 2020];13(1):38. Disponible en: https://link.springer.com/article/10.1007/s11657-018-0453-5

Wang J, Wang X, Fang Z, Lu N, Han L. Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults. Clinics (Sao Paulo) [Internet]. 2017 [citado 12 Sep 2020];72(5):289-93. Disponible en: https://www.scielo.br/scielo.php?pid=S1807-59322017000500289&script=sci_arttext

Sharma A, Sinha RJ, Singh V, Garg G, Agarwal S, Pandey S. Implications of the Fracture Risk Assessment Algorithm for the assessment and improvement of bone health in patients with prostate cancer: A comprehensive review. Turk J Urol [Internet]. 2019 [citado 12 Sep 2020];45(4):245-53. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619849/

Cuba. Centro Nacional de Información de Ciencias Médicas. Biblioteca Médica Nacional. VIH/Sida. Estadisticas Mundiales. Factográfico salud [Internet]. 2018 Feb [citado 12 Sep 2020]; 4(2):[aprox. 13 p.]. Disponible en: http://files.sld.cu/bmn/files/2018/02/factografico-de-salud-febrero-2018.pdf

Samji H, Cescon A, Hogg RS, Modur SP, Althoff KN, Buchacz K, et al. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PloS One [Internet]. 2013 [citado 12 Sep 2020];8(12):e81355. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867319/

Gullón Ojesto A, García Vadillo JA. Osteoporosis in human immunodeficiency virus-infected patients Seminarios de la Fundación Española de Reumatología. Principio del formulario [Internet]. 2013 [citado 12 Sep 2020];14(1):18-23. Diponible en: https://www.sciencedirect.com/science/article/abs/pii/S1577356612000681

Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. The Lancet [Internet]. 2013 [citado 12 Sep 2020];382(9903):1525-33. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0140673613618097

Reyes Llerena GA, Guibert Toledano M, Millán Marcelo C, Pérez Ávila J, Cataneda Yarman DP, Navarro Camero A, et al. New and Old Forms of Rheumatic Manifestations associated with HIV-AIDS Infection: 25 Years after the Beginning of the Epidemic in Cuba. Panamerican Congress of rheumatology. J Clinical Rheumatology [Internet]. 2018 [citado 12 Sep 2020];24:S172-3. Disponible en: https://journals.lww.com/jclinrheum/Fulltext/2018/04001/Abstracts,_20th_PANLAR_Meeting__Buenos_Aires,.1.aspx

Premaor MO, Compston JE. The hidden burden of fractures in people living with HIV. JBMR Plus [Internet]. 2018 [citado 12 Sep 2020];2(5):247-56. Disponible en: https://asbmr.onlinelibrary.wiley.com/doi/abs/10.1002/jbm4.10055

Reyes Llerena GA, Guibert Toledano M, Torres Figueroa A, Navarro Camero A, Torres Carballeira R, Reyes Guibert G, et al. Enfermedades reumáticas y complicaciones metabólicas en pacientes con VIH-SIDA con tratamiento antirretroviral de alta eficiencia Rev Cubana Reumatol [Internet]. 2018 [citado 12 Sep 2020];20(3):e650. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-59962018000300005&lng=es

Grey A, Bolland MJ, Horne A, Wattie D, House M, Gamble G. Five years of anti-resorptive activity after a single dose of zoledronate results from a randomized double-blind placebo-controlled trial. Bone [Internet].2012 [citado 12 Sep 2020];50(6):1389-93. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S875632821200734X

Mondy K, Powderly WG, Claxton SA, Yarasheski KH, Royal M, Stoneman JS. Alendronate, vitamin D and calcium for the treatment of osteopenia/osteoporosis associated to HIV infection. J Adquir Immune Defic Syndr [Internet].2005 [citado 12 Sep 2020];38(4):426-31. Disponible en: https://journals.lww.com/jaids/fulltext/2005/04010/Alendronate,_Vitamin_D,_and_Calcium_for_the.7.aspx?casa_token=w3fbxShWOn8AAAAA:1ZBzB2HOV1idCOKVM5TDG5FkofQPshZRY3X8gLSNYrXcbSDdRObAWmBeBgL5dNZXWepXKTfAT4KYpGavz-EaAXaPBEFK5_A

Dong HV, Cortes YI, Shiau S, Yin MT. Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis. AIDS [Internet]. 2014 [citado 12 Sep 2020];28(14):2119-31. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940983/

Mahungu TW, Rodger AJ. Johnson MA. HIV as a chronic disease. Clinical Medicine. 2009;9(2),125.

Kanis JA, Harvey NC, Cooper C, Johansson H, Odén A, McCloskey EV, et al. A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation. Arch Osteoporos [Internet]. 2016 [citado 12 Sep 2020];11(1):25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27465509/

Brown TT, Hoy J, Borderi M, Guaraldi G, Renjifo B, Vescini F, et al. Recommendations for Evaluation and Management of Bone Disease in HIV. Clinical Infectious Diseases [Internet] 2015 [citado 12 Sep 2020];60(8):1242-51. Disponible en: https://academic.oup.com/cid/article/60/8/1242/2462854?login=true

Yin MT, Falutz J. How to predict risk of fracture in HIV. Curr Opin HIVAIDS [Internet]. 2016 [citado 10 Oct 2020];11(3):261-7. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399770/

Amiel C, Ostertag A, Siama L, Baudoin C, N’Guyen T, Lajeunie E, et al. BMD is reduced in HIV infected men irrespective of treatment. J Bone Miner Res [Internet]. 2004 [citado 10 Oct 2020];19(3):402-9. Disponible en: https://asbmr.onlinelibrary.wiley.com/doi/abs/10.1359/JBMR.0301246

Biver E, Calmy A, Aubry-Rozier B, Birkhäuser M, Bischoff-Ferrari HA, Ferrari S, et al. Diagnosis, prevention, and treatment of bone fragility in people living with HIV: a position statement from the Swiss Association against Osteoporosis. Osteoporos Int [Internet]. 2019 [citado 10 Oct 2020];30(5):1125-35. Disponible en: https://link.springer.com/article/10.1007/s00198-018-4794-0

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