Síndrome de Evans en paciente con síndrome antifosfolipídico secundario: Desafío terapéutico
Keywords:
síndrome de Evans, síndrome antifosfolipídico, lupus eritematoso sistémico, hemorragia cerebral, trombosis venosaAbstract
El síndrome de Evans, es caracterizado por la presencia de anemia hemolítica autoinmune y púrpura trombocitopénica, presentándose con menor frecuencia en pacientes con diagnóstico de lupus eritematoso sistémico. La asociación de estas dos entidades con el síndrome de anticuerpos antifosfolípidos se torna inusual, constituyendo un desafío diagnóstico y a la vez terapéutico para el clínico. Presentamos un paciente con lupus eritematoso sistémico, que desarrollo síndrome de Evans y síndrome antifosfolípido, complicado con hemorragia intracerebral cisternal y trombosis venosa profunda de miembros superiores.Downloads
References
Costallat GL, Appenzeller S, Costallat LT. Evans syndrome and Systemic Lupus Erythematosus: Clinical presentation and outcome. Joint Bone Spine. 2012;79(4): 362–64
Domiciano DS, Shinjo SK. Autoimmune hemolytic anemia in systemic lupus erythematosus: association with thrombocytopenia. Clin Rheumatol. 2010; 29:1427-31.
Dhingra KK, Jain D, Mandal S, Khurana N, Singh T, Gupta N. Evans syndrome: a study of six cases with review of literature. Hematology. 2008;13:356-60.
Muraoka I, Adachi N, Ogashiwa M, Segawa H. Cerebral hemorrhage in a case of antiphospholipid antibody syndrome. No To Shinkei. 1993;45:263–66.
Boura P, Papadopoulos S, Tselios K, Skendros P, Dioritou O, Malamis G, et al. Intracerebral hemorrhage in a patient with SLE and catastrophic antiphospholipid syndrome (CAPS): report of a case. Clin Rheumatol. 2005;24:420-4.
Jung F, Miesbach W, Scharrer I. Cardiac and cerebral manifestations of antiphospholipid syndrome. Z Kardiol. 2002;91:650-58
Duyckaerts C, Hauw JJ. Pathology and pathophysiology of brain ischaemia. Neuroradiology. 1985;27:460-67.
Smith RW, Ellison DW, Jenkins EA, Gallagher PJ, Cawley MI. Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases. Ann Rheum Dis. 1994; 53:327-30.
Arinuma Y, Kikuchi H, Aramaki K, Kyogoku M, Hirohata S. Histopathological analysis of cerebral hemorrhage in systemic lupus erythematosus complicated with antiphospholipid syndrome. Mod Rheumatol. 2011;21:509-13
Rodríguez García JL, Khamashta MA. Clinical advances of interest in the diagnosis and treatment of patients with antiphospholipid syndrome. Rev Clin Esp. 2013;213(2):108-13
Ruiz-Irastorza G, Martinez-Berriotxoa A, Egurbide MV. The antiphospholipid syndrome in the 21st century. Med Clin. 2009;133(10):390-96.
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