El valor de los autoanticuerpos: de la teoria al laboratorio clinico

Christian Blas La Rosa Fabian

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Resumen

La prueba de autoanticuerpos es cada vez más relevante en el diagnóstico de las enfermedades autoinmunes. Como consecuencia, la detección de autoanticuerpos se reconoce cada vez más en los criterios de clasificación y las directrices de diagnóstico. Es importante conocer la presencia de los autoanticuerpos naturales y las características que permiten su diferenciación con los autoanticuerpos patológicos. Varias características especiales de los auto anticuerpos y el desarrollo de nuevas metodologías hacen que la interpretación correcta de los resultados de las pruebas de anticuerpos sea cada vez más difícil. En este artículo se revisa las características del autoanticuerpo, su reconocimiento como un analito heterogéneo y su implicancia en los métodos de detección, asi como la utilidad en la práctica clínica. 

Palabras clave

autoanticuerpos; enfermedad autoinmune; métodos inmunológicos; laboratorio clínico

Referencias

Robbins WC, Holman HR, Deicher H, Kunkel HG. Complement fixation with cell nuclei and DNA in lupus erythematosus. Proc Soc Exp Biol Med. 1957;96(3):575-9.

Miescher P, Fauconnet M. Absorption of L. E. factor by isolated cell nuclei. Experientia. 1954;10(6):252-3.

Mackay IR. Travels and travails of autoimmunity: a historical journey from discovery to rediscovery. Autoimmun Rev. 2010;9(5):A251–A258.

Patakas A, Benson RA, Withers DR, Conigliaro P, McInnes IB, Brewer JM, et al. Th17 effector cells support B cell responses outside of germinal centres. PloS One. 2012;7: e49715.

Matzinger P, Tolerance, damage, and the extenden familiy. Annual Review of Inmunology. 1994.12:991-1045.

Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, Thomas SR, Zhang N, et al. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med. 2012;209:2065-77.

Shoenfeld Y, Isenberg DA. The mosaic of autoimmunity. Immunol Today. 1989;10:123-6.

Amital H, Eric Gershwin M, Shoenfeld Y. Reshaping the mosaic of autoimmunity. Semin Arthritis Rheum. 2006;35:341-3.

George J, Gilburd B, Shoenfeld Y. The emerging concept of pathogenic natural autoantibodies. Hum Antibodies. 1997:8(2):70-5.

Elkon K, Casali P. Nature and functions of autoantibodies. Nat Clin Pract Rheumatol. 2008;4(9):491-8.

Chen C, Stenzel-Poore MP, Rittenberg MB. Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3. J Immunol. 1991;147:2359-67.

Notkins AL. Polyreactivity of antibody molecules. Trends Immunol. 2004;25:174-9.

Mahler M, Pierangeli S, Meroni PL, Fritzler MJ. Autoantibodies in systemic autoimmune disorders. J Immunol Res. 2014;2014:1-2.

Shoenfeld Y, Toubi E. Protective autoantibodies: role in homeo- stasis, clinical importance, and therapeutic potential. Arthritis Rheum. 2005;52(9):2599-606.

Wildbaum G, Nahir MA, Karin N. Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self- destructive immunity. Immunity. 2003;19(5):679-88.

Rahyab AS, Alam A, Kapoor A, Zhang M. Natural antibody – biochemistry and functions. Glob J Biochem. 2011;2(4):283-8.

Lane SK, Gravel JW Jr. Clinical utility of common serum rheumatologic tests. Am Fam Physician. 2002;65(6):1073-80.

Bizzaro N. The predictive significance of autoantibodies in organ-specific autoimmune diseases. Clin Rev Allergy Immunol. 2008;34(3):326-31.

Alspaugh MA, Tan EM. Antibodies to cellular antigens in Sjogren's syndrome. J Clin Invest. 1975;55:1067-73.

Kurata N, Tan EM. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis. Arthritis Rheum. 1976;19:574-80.

Martins TB, Burlingame R, von Mühlen CA, Jaskowski TD, Litwin CM, Hill HR. Evaluation of multiplexed fluorescent microsphere immunoassay for detection of autoantibodies to nuclear antigens. Clin Diagn Lab Immunol. 2004;211:1054‐9.

Desplat‐Jego S, Bardin N, Larida B, Sanmarco M. Evaluation of the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional methods. Ann N Y Acad Sci. 2007;1109:245‐55.

Hanly JG, Thompson K, McCurdy G, Wilton K. Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus. J Immunol Methods. 2010;352:147‐52.

Copple SS, Martins TB, Masterson C, Joly E, Hill HR. Comparison of three multiplex immunoassays for detection of antibodies to extractable nuclear antibodies using clinically defined sera. Ann N Y Acad Sci. 2007;1109:464-72.

Eissfeller P, Sticherling M, Scholz D, Hennig K, Lüttich T, Motz M, et al. Comparison of different test systems for simultaneous autoantibody detection in connective tissue diseases. Ann N Y Acad Sci. 2005;1050:327‐39.

Pereira KM, Dellavance A, Andrade LE. The challenge of identification of autoantibodies specific to systemic autoimmune rheumatic diseases in high throughput operation: proposal of reliable and feasible strategies. Clin Chim Acta. 2014;437:203‐10.

Conrad K, Andrade LEC, Chan EKL, Pruijn GJM, Steiner G, Shoenfeld Y (eds). From Autoantibody Research to Standardized Diagnostic Assays in the Management of Human Diseases, Report on the 12th Dresden Symposium on Autoantibodies. Lengerich: Ed. Pabst Science Publishers; 2015.

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham 3rd CO, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/ European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69:1580-8.

Van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/ European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2013;72:1747-55.

Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guide- lines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54:136-60.

Nell VP, Machold KP, Eberl G, Stamm TA, Uffmann M, Smolen JS. Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology. 2004;43:906-14.

Steen V, Medsger Jr TA. Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement. Arthritis Rheum. 2003;48:516-22.

Conrad K, Roggenbuck D, Reinhold D, Sack U. Autoantibody diagnostics in clinical practice. Autoimmun Rev. 2012;11:207-11.

DOI: http://dx.doi.org/10.5281/zenodo.1173741

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