Chikungunya virus infection and its possible relationship with neurological isolated syndrome: an emerging hypothesis

Authors

  • Eneida Barrios Lamoth Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0000-0002-2774-9930
  • José Pedro Martínez Larrarte Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0000-0003-1380-2646
  • Silvia María Pozo Abreu Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0000-0001-7125-3572
  • Elismenia Fernández Hernández Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0009-0002-7331-2964

Keywords:

fiebre Chikungunya, virus Chikungunya, síndrome neurológico aislado

Abstract

Chikungunya fever, caused by the Chikungunya virus (CHIKV) of the Alphavirus genus, is an arboviral disease of increasing global importance, classically characterized by high fever and debilitating arthralgia. However, the spectrum of the disease has expanded to include severe and often underdiagnosed neurological manifestations. Through this letter, we wish to highlight a possible association between CHIKV infection and the presentation of Neurologically Isolated Syndrome (NES), a concept that warrants further investigation for early diagnosis and management.

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References

1. Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T. The neurological complications of chikungunya virus: A systematic review. Rev Med Virol. 2018;28(3):e1978.

2. Silva MMO, Tauro LB, Kikuti M. Concomitant transmission of dengue, chikungunya, and Zika viruses in Brazil: Clinical and epidemiological findings from surveillance for acute febrile illness. Clin Infect Dis. 2019;69(8):1353-9.

3. Muñoz LS, Barreras P, Pardo CA. Chikungunya Virus Infections in the Nervous System: Current Findings and Prospects. Curr Infect Dis Rep. 2017;19(3):11.

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Published

2025-11-12

How to Cite

1.
Barrios Lamoth E, Martínez Larrarte JP, Pozo Abreu SM, Fernández Hernández E. Chikungunya virus infection and its possible relationship with neurological isolated syndrome: an emerging hypothesis. Rev. cuba. de Reumatol. [Internet]. 2025 Nov. 12 [cited 2025 Dec. 6];27. Available from: https://revreumatologia.sld.cu/index.php/reumatologia/article/view/1485

Issue

Vol. 27 (2025): Publicación continua

Section

Letters to the editor

License

Copyright (c) 2025 Eneida Barrios Lamoth, José Pedro Martínez Larrarte , Silvia María Pozo Abreu, Elismenia Fernández Hernández

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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