Chikungunya virus infection and its possible relationship with neurological isolated syndrome: an emerging hypothesis

Authors

  • Eneida Barrios Lamoth Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0000-0002-2774-9930
  • Dinorah Marisabel Prada Hernández Universidad de Ciencias Médicas de la Habana. Centro de Referencia para las Enfermedades Reumáticas. Hospital Docente Clínico Quirúrgico 10 de Octubre. La Habana https://orcid.org/0000-0002-7499-4146
  • Jorge Alexis Gómez Morejón Universidad de Ciencias Médicas de la Habana. Centro de Referencia para las Enfermedades Reumáticas. Hospital Docente Clínico Quirúrgico 10 de Octubre, La Habana https://orcid.org/0000-0002-4234-9396
  • Silvia María Pozo Abreu Universidad de Ciencias Médicas de la Habana. Centro de Referencia para las Enfermedades Reumáticas. Hospital Docente Clínico Quirúrgico 10 de Octubre, La Habana https://orcid.org/0000-0001-7125-3572
  • Elismenia Fernández Hernández Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0009-0002-7331-2964
  • José Pedro Martínez Larrarte Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana https://orcid.org/0000-0003-1380-2646

Keywords:

Chikungunya fever, Chikungunya virus, isolated neurological syndrome

Abstract

Chikungunya fever, caused by the Chikungunya virus (CHIKV) of the Alphavirus genus, is an arboviral disease of increasing global importance, classically characterized by high fever and debilitating arthralgia. However, the spectrum of the disease has expanded to include severe and often underdiagnosed neurological manifestations. Through this letter, we wish to highlight a possible association between CHIKV infection and the presentation of Neurologically Isolated Syndrome (NES), a concept that warrants further investigation for early diagnosis and management.

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Author Biographies

Eneida Barrios Lamoth, Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana

Especialista de Medicina General Integral, Especialista en inmunología, Profesora asistente

Dinorah Marisabel Prada Hernández, Universidad de Ciencias Médicas de la Habana. Centro de Referencia para las Enfermedades Reumáticas. Hospital Docente Clínico Quirúrgico 10 de Octubre. La Habana

MSc, Especialista de Medicina General Integral, Especialista de Reumatología de 2do Grado, Profesor Auxiliar

Jorge Alexis Gómez Morejón, Universidad de Ciencias Médicas de la Habana. Centro de Referencia para las Enfermedades Reumáticas. Hospital Docente Clínico Quirúrgico 10 de Octubre, La Habana

MSc, Especialista de Medicina General Integral, Especialista de Reumatología de 2do Grado, Profesor Auxiliar

Silvia María Pozo Abreu, Universidad de Ciencias Médicas de la Habana. Centro de Referencia para las Enfermedades Reumáticas. Hospital Docente Clínico Quirúrgico 10 de Octubre, La Habana

MSc. Especialista de Medicina General Integral, Especialista en Bioestadística, Profesora asistente

Elismenia Fernández Hernández, Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana

Técnica en Laboratorio Clínico, Asistente Técnico Docente

José Pedro Martínez Larrarte , Universidad de Ciencias Médicas de La Habana. Facultad de Ciencias Médicas Miguel Enríquez. Laboratorio Central de Líquido Cefalorraquídeo (LABCEL). La Habana

MSc. Especialista de 2do Grado en Reumatología, Investigador auxiliar, Profesor consultante

References

1. Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T. The neurological complications of chikungunya virus: A systematic review. Rev Med Virol. 2018;28(3):e1978.

2. Silva MMO, Tauro LB, Kikuti M. Concomitant transmission of dengue, chikungunya, and Zika viruses in Brazil: Clinical and epidemiological findings from surveillance for acute febrile illness. Clin Infect Dis. 2019;69(8):1353-9.

3. Muñoz LS, Barreras P, Pardo CA. Chikungunya Virus Infections in the Nervous System: Current Findings and Prospects. Curr Infect Dis Rep. 2017;19(3):11.

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Published

2025-11-12 — Updated on 2026-01-06

How to Cite

1.
Barrios Lamoth E, Prada Hernández DM, Gómez Morejón JA, Pozo Abreu SM, Fernández Hernández E, Martínez Larrarte JP. Chikungunya virus infection and its possible relationship with neurological isolated syndrome: an emerging hypothesis. Rev. cuba. de Reumatol. [Internet]. 2026 Jan. 6 [cited 2026 Jan. 30];27:e1485. Available from: https://revreumatologia.sld.cu/index.php/reumatologia/article/view/1485

Issue

Vol. 27 (2025): Publicación continua

Section

Letters to the editor

License

Copyright (c) 2025 Eneida Barrios Lamoth, Dinorah Marisabel Prada Hernánde, Jorge Alexis Gómez Morejón, Silvia María Pozo Abreu, Elismenia Fernández Hernández, José Pedro Martínez Larrarte

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