Efectos adversos tras el uso parenteral del Metotrexate
Keywords:
efectos adversos, vía parenteral, metotrexateAbstract
El metotrexate es un citostático que ha ganado amplia aceptación en el tratamiento de la artritis reumatoide y otras enfermedades reumáticas. El medicamento es un antagonista del ácido fólico. Este debe ser reducido en el or ganismo a ácido dihidrofólico y tetrahidrofólico. El MTX posee una gran afinidad por la enzima dihidrofolato reductasa, de forma tal que su ac ción altera la reducción del ácido dihidrofólico a tetrahidrofólico y la donación de una parte de la molécula para la síntesis de nucleótidos purínicos. Por tanto, inhibe la síntesis de ARN y ADN necesarios para la proliferación celular, como ocu rre en la sinovitis reumatoideaDownloads
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