Atherogenic risk in rheumatoid arthritis patients. Classification beginning with immunoinflamatory response variables
Keywords:
rheumatoid arthritis, coronary risk, atherogenic index, rheumatoid factorAbstract
The early coronary risk’s classification in rheumatoid arthritis patients is a necessity during approach them, yet. To evaluate the discriminatory capacity between coronary risk’s categories of the rheumatoid factor, c reactive protein, complement C3, complement C4 and 28 joint count Disease Activity Score variables carried out an observational analytic cross sectional study in a Matanzas rheumatoid arthritis patients group. The coronary risk’s categories was defined as minor and major according lipoprotein(a), apolipoprotein B/ apolipoprotein A1, LDL/HDL cholesterol, apolipoprotein B/LDL cholesterol and atherogenic ratio’s values within or without of reference rank, respectively. The 18.0 version statistic software SPSS was used for discriminatory analysis. The DAS28, complement C3 and C reactive protein defined discriminatory functions between the coronary risk categories according to the LDL/HDL cholesterol, apolipoprotein B/ apolipoprotein A1 and apolipoprotein B/LDL cholesterol, respectively [F > 3.84; Wilks’s Lambda, p < 0.05]. In every set the discriminatory function showed more than 50 % of global right classification of patients analized. Cut off in 5,75; 7.35 mg/L, and 1.13 Gr/L for 28 joint count Disease Activity Score, C reactive protein, and complement C3, respectively, showed suitable discriminatory capacity [area under curve > 0.5 (p < 0.05); positive probable ratio ≥ 1.5]. The results showed possibility of stratifying directly coronary risk linked lipoprotein metabolism beginning with DAS28, C reactive protein, and complement C3 in rheumatoid arthritis patients.
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