Chronic Recurrent Multifocal Osteomyelitis: presentation of case
Keywords:
chronic recurrent multifocal osteomyelitis, CRMO, autoinflammatory disease, multiple osteolytic lesionsAbstract
Autoinflammatory syndromes are a group of diseases characterized by spontaneous, recurrent or persistent episodes of multisystem inflammation. They do not show an infectious, neoplastic or autoimmune etiology. They are caused by alterations of the innate immunity, which causes a dysregulation of the inflammatory system at the level of the inflammasome. These syndromes are subdivided into two major groups, the hereditary syndromes of periodic fever and the persistent autoinflammatory diseases; within the latter are the inflammatory bone diseases which chronic recurrent multifocal osteomyelitis. We present a case of a 9-year-old girl who enters our hospital due to a prolonged febrile syndrome and after multiple investigations, it concludes as a Chronic Recurrent Multifocal Osteomyelitis.
Downloads
References
Russo RAG, Katsicas MM. Enfermedades autoinflamatorias. Medicina (B. Aires) [Internet]. 2016 [citado jul 2017];76(3). Disponible en: http://www.scielo.org.ar/pdf/medba/v76n3/v76n3a07.pdf
Almeida De Jesus D, Goldbach-Mansky R. Monogenic autoinflammatory diseases: concept and clinical manifestations. Clin Immunol [Internet]. 2013 [citado ago 2017];147(3). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769788/pdf/nihms485557.pdf
Morbach H, Hedrich CM, Beer M, Girschick HJ. Autoinflammatory bone disorders. Clin Immunol [Internet]. 2013 [citado ago 2017];147(3). Disponible en: http://www.sciencedirect.com/science/article/pii/S1521661612003129?via%3Dihub
Sharma M, Ferguson PJ. Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers. Curr Opin Rheumatol [Internet]. 2013 [citado Ago 2017];25(5). Diponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912130/pdf/nihms791946.pdf
Gallego Eusse HD, Velásquez-Franco CJ, Mesa Navas MA. Osteomielitis crónica multifocal recurrente: estado del arte. MEDICINA [Internet]. 2016 [citado Ago 2017]; 35(1). Disponible en: https://revistas.upb.edu.co/index.php/Medicina/article/view/6915/6318
Pardo Esteban S, Contreras Suay J, Ballestín Vicente J, Rometsch S, Ferrer González P, Adell Sales A, et al. Osteomielitis crónica multifocal recurrente. Acta Pediatr Esp [Internet]. 2014 [citado Ago 2017];72(5). Disponible en: https://www.researchgate.net/profile/Antonio_Martinez_Carrascal2/publication/265294949_Osteomielitis_crnica_multifocal_recurrente/links/5408c6030cf2187a6a6d8d2b.pdf
Albi Rodríguez G. Valoración radiológica de imágenes líticas óseas. Pediatr integral [Internet]. 2012 [citado Ago 2017];XVI(7).Disponible en : https://issuu.com/pediatria-integral/docs/p.i_vol._xvi_num._07_sep_2012 __
Hofmann SR, Roesen-Wolff A, Hahn G, Hedrich CM. Update: cytokine dysregulation in chronic nonbacterial osteomyelitis (CNO). Int J Rheumatol [Internet]. 2012 [citado Ago 2017];2012. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364585/pdf/IJR2012-310206.pdf
Guillén Martín S, Belda Hofheinz S, Rojo Conejo P, Losada Pinedo B, Ramos Amador JT, Clemente Pollan J, et al. Osteomielitis crónica multifocal recurrente. An Pediatr (Barc) [Internet]. 2005 [citado Ago 2017];62(6). Disponible en: http://www.analesdepediatria.org/es/osteomielitis-cronica-multifocal-recurrente/articulo/13075550/
Barral Mena E, Freire Gómez X, Enríquez Merayo E, Casado Picón R, Bello Gutierrez P, Arocen JI. Osteomielitis crónica no bacteriana: experiencia en un hospital terciario. An Pediatr (Barc) [Internet]. 2016 [citado Ago 2017];85(1). Disponible en: http://www.analesdepediatria.org/en/non-bacterial-chronic-osteomyelitis-experience-in/articulo/S2341287916300072/
Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep [Internet]. 2012 [citado Ago 2017];14(2). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656493/pdf/nihms365610.pdf
Hedrich CM, Hahn G, Girschick HJ, Morbach H. A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. Expert Rev Clin Immunol [Internet]. 2013 [citado Ago 2017]; 9: 845-854. Disponible en: https://www.semanticscholar.org/paper/A-clinical-and-pathomechanistic-profile-of-chronic-Hedrich-Hahn/9606c98fc52c2e21474aad6e3dc7fd16ac99e43e
Regueras Santos L, Ledesma Benítez I, Ferrero de la Mano LJ, Del Río González E, Fernández Castaño MT. Osteomielitis crónica multifocal recurrente (OCMR). Experiencia en nuestro Servicio. Bol Pediatr [Internet]. 2007 [citado Ago 2017];47. Disponible en: http://sccalp.org/documents/0000/0473/BolPediatr2007_47_136-141.pdf
Estrada-Castrillón M, Ruiz-Zabaleta TI. Osteomielitis crónica multifocal recurrente: presentación de un caso. Rev CES Med [Internet]. 2011 [citado Ago 2017]; 25(1). Disponible en: http://www.scielo.org.co/pdf/cesm/v25n1/v25n1a10.pdf
Osteomyelitis Multifocal Recurrente Crónica (CRMO) [Internet]. Autoinflammatory Alliance; c2014-17 [actualizado 3 mar 2016; citado 12 Ago 2017]. Disponible en: http://www.nomidalliance.es/crmo.php
Borzutzky A, Stern S, Reiff A, Zurakowski D, Steinberg EA, Dedeoglu F, et al. Pediatric chronic nonbacterial osteomyelitis. Pediatrics [Internet]. 2012 [citado Ago 2017];130(5). Disponible en: https://pediatrics.aappublications.org/content/130/5/e1190.long
Watanabe T, Ono H, Morimoto Y, Otsuki Y, Shirai M, Endoh A, et al. Skull involvement in a pediatric case of chronic recurrent multifocal osteomyelitis. Nagoya J Med Sci [Internet]. 2015 [citado Ago 2017];77. Disponible en: http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/773/32_Watanabe.pdf
Published
How to Cite
Issue
Section
License
Warning of rights of author
The authors that publish in this journal agree with the following terms:
The authors conserve the rights of author and concede to the journal the right of the first publication, fulfilling with the license Creative Commons Attribution License that allows to others share the work with recognition of the authorship of their articles, and the initial publication in this journal.
The authors can establish separately additional agreements for the no exclusive distribution of the version of the work published in the journal (for example, situate it in an institutional repository, in a personal blog or publish it partial or totally in a book), with a recognition of their initial publication in this journal.
To be able to send the manuscript or part of him passed three months of published, for his evaluation to other publishers, identifying it or not with the same title; whenever allusion is made to our journale and know it the new publisher.
The publishing committee of the Cuban Journal of Rheumatology authorizes to other publishers, to reproduce the articles published in our magazine, whenever it indicate the origin of the same.
The authors should send a document in Office Word application format through the electronic address of the magazine with a similar format to that we include next:
---------------------------------------------------------------------------------------------------------------------
Statement of authorship and cede of articles for the publication of the scientific work in the Cuban Journal of Rheumatology
Date:
Those who subscribe certify that are the authors of the work:
Of this form communicate the originality of our article clearing that the concepts and knowledges of other authors that have included in the text of the article, have been quoted properly in the bibliography.
We do proof besides that the article in question is original and has not been published, total neither partially, in another journal.
To be approved for his publication in the Cuban Journal of Rheumatology, do secession of the rights of publication to the same one through the method that realizes it usually.
In front of any catchword that exist by the article that send to evaluate, relieve of of the responsibility to the Cuban Journal of Rheumatology holding us responsible with all the difficulties that can berelated by any situation.
We include to continuation the name and the signature of all authors and collaborators of this article.
Name: Signature:
