La melatonina y su rol en los procesos inflamatorios
Keywords:
melatonina, inflamación, enfermedades autoinmunes, enfermedades reumatológicasAbstract
La melatonina es una hormona neuroendocrina pleiotrópica, producida principalmente por la glándula pineal que regula el ritmo circadiano, es antiinflamatoria, inmunomoduladora, neuroprotectora, antioxidante. Se realizó una revisión sobre el tema empleando artículos de libre acceso en la base de datos Pubmed en el período de enero del 2013 a septiembre del 2018 con el objetivo de describir el rol de esta biomolécula en algunas enfermedades autoinmunes y reumatológicas, así como en otros procesos inflamatorios agudos y crónicos. La melatonina ha demostrado acciones favorables cuando se administra en enfermedades como la esclerosis múltiple, diabetes mellitus tipo l, cáncer. No obstante, puede empeorar las crisis en la artritis reumatoide.
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