Observaciones clínicas en pacientes con artritis reumatoide tratados con anticuerpo monoclonal T1h (anti CD6)
Keywords:
artritis reumatoide, anticuerpo monoclonal, T1h anti-CD6, Health Assessment Questionnaire, HAQ-CUAbstract
En el presente trabajo se exponen los resultados preliminares de 5 pacientes con artritis reumatoide tratados con anticuerpo monoclonal T1h (anti-CD6) utilizando un nivel de dosis de 0.4 mg/kg/dosis. En 4 de los 5 pacientes estudiados se logró respuesta clínica ACR > 20 a las 24 semanas de evaluación. Hubo una disminución importante en el número de articulaciones dolorosas e inflamadas más marcado en estas últimas. En la evaluación del Health Assessment Questionnaire-Cuba a las 24 semanas el 60% de los pacientes presentaron discapacidad ligera y 1 paciente sin discapacidad (Health Assessment Questionnaire = 0). Los eventos adversos más frecuentes fueron fiebre y escalofríos de leve intensidad, No se presentaron infecciones oportunistas asociadas a la administración.Downloads
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