Pathogenesis of rheumatoid arthritis, current therapeutic management and future prospects
Keywords:
pathogenesis of rheumatoid arthritis, main subtypes, current therapeutic management, future perspectivesAbstract
Rheumatoid arthritis is a chronic systemic autoimmune disease that arises more frequently in women than in men, and is predominantly observed in the elderly. To present the result of a bibliographic review on general aspects related to the pathogenesis of rheumatoid arthritis and current therapeutic management, as well as future perspectives of new therapeutic approaches. There are two main subtypes of rheumatoid arthritis according to the presence or absence of anti-citrullinated protein antibodies. Citrullination is catalyzed by the calcium-dependent enzyme peptidylarginine deiminase, which changes a positively charged arginine to a polar but neutral citrulline as a result of post-translational modification. This work focuses on the anti-citrullinated protein antibodies -positive rheumatoid arthritis subset and divides the progression of the rheumatoid arthritis process into several stages. It should be mentioned that these stages can occur sequentially or simultaneously. A better understanding of how pathological mechanisms drive the deterioration of rheumatoid arthritis progression in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of disease progression.
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References
Silman AJ, Pearson JE. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res [Internet]. 2002 [citado 12 Jul 2021];4(Suppl.3):S265-72. Disponible en: https://arthritis-research.biomedcentral.com/articles/10.1186/ar578
Cho SK, Kim D, Won S, Lee J, Choi CB, Choe JY, et al. Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis. Korean J Intern Med [Internet]. 2019 [citado 12 Jul 2021];34(4):910-6. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610196/
Raza K, Stack R, Kumar K, Filer A, Detert J, Bastian H, et al. Delays in assessment of patients with rheumatoid arthritis: variations across Europe. Ann Rheum Dis [Internet]. 2011 [citado 12 Jul 2021];70(10):1822-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21821867/
Ometto F, Botsios C, Raffeiner B, Sfriso P, Bernardi L, Todesco S, et al. Methods used to assess remission and low disease activity in rheumatoid arthritis. Autoimmun Rev [Internet]. 2010 [citado 12 Jul 2021];9(3):161-4. Disponible en:
Grennan DM, Gray J, Loudon J, Fear S. Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery. Ann Rheum Dis [Internet]. 2001 [citado 12 Jul 2021];60(3):214-7. Disponible en: https://ard.bmj.com/content/60/3/214.full
Bizzaro N, Bartoloni E, Morozzi G, Manganelli S, Riccieri V, Sabatini P, Filippini M, et al. Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study. Arthritis Res Ther [Internet]. 2013 [citado 12 Jul 2021];15(R16):1-9. Disponible en: https://link.springer.com/article/10.1186/ar4148
Padyukov L, Seielstad M, Ong RT, Ding B, Rönnelid J, Seddighzadeh M, et al. A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis [Internet]. 2011 [citado 12 Jul 2021];70(2):259-65. Disponible en: https://ard.bmj.com/content/70/2/259.short
Seegobin SD, Ma MH, Dahanayake C, Cope AP, Scott DL, Lewis C, et al. ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial. Arthritis Res Ther [Internet]. 2014 [citado 12 Jul 2021];16(R13):1-12. Disponible en: https://link.springer.com/article/10.1186/ar4439
Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet [Internet]. 2012 [citado 12 Jul 2021];44:291-6. Disponible en: https://www.nature.com/articles/ng.1076
Okada Y, Kim K, Han B, Pillai NE, Ong RT, Saw WY, et al. Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum Mol Genet [Internet]. 2014 [citado 12 Jul 2021];23(25):6916-26. Disponible en: https://academic.oup.com/hmg/article/23/25/6916/569541?login=true
Nabi G, Akhter N, Wahid M, Bhatia K, Mandal RK, Dar SA, et al. Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population. Autoimmunity [Internet]. 2016 [citado 12 Jul 2021];49(3):197-210. Disponible en: https://www.tandfonline.com/doi/abs/10.3109/08916934.2015.1134514
Goh LL, Yong MY, See WQ, Wing Chee EY, Lim PQ, Leong KP. NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese. Rheumatol Int [Internet]. 2017 [citado 12 Jul 2021];37:1295-1302. Disponible en: https://link.springer.com/article/10.1007/s00296-017-3762-x#citeas
McCarthy C, Orr C, Fee LT, Carroll TP, Dunlea DM, Hunt DJ, et al. Brief report: genetic variation of the alpha1 -antitrypsin gene is associated with increased autoantibody production in rheumatoid arthritis. Arthritis Rheumatol [Internet]. 2017 [citado 12 Jul 2021];69(8):1576-9. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/art.40127
Castañeda-Delgado JE, Bastián-Hernández Y, Macias-Segura N, Santiago-Algarra D, Castillo-Ortiz JD, Alemán-Navarro AL, et al. Type I interferon gene response is increased in early and established rheumatoid arthritis and correlates with autoantibody production. Front Immunol [Internet]. 2017 [citado 12 Jul 2021];8:285. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28373872/
Kuo CF, Grainge MJ, Valdes AM, See LC, Yu KH, Shaw SW, et al. Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study. Rheumatology [Internet]. 2017 [citado 12 Jul 2021];56(6):928-33. Disponible en: https://europepmc.org/article/pmc/pmc5850742
van der Woude D, Alemayehu W, Verduijin W, de Vries RR, Houwing-Duistermaat JJ, Huizinga TW, et al. Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis. Nat Genet [Internet]. 2010 [citado 12 Jul 2021];42:814-6. Disponible en: https://www.nature.com/articles/ng1010-814
Klaresko L, Stolt P, Lundberg K, Kallberg H, Bengtsoon C, Grunewald J, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum [Internet]. 2006 [citado 12 Jul 2021];54(1):38-46. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/art.21575
Meng W, Zhu Z, Jiang X, Too CL, Uebe S, Jagodic M, et al. DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis. Arthritis Res Ther [Internet]. 2017 [citado 12 Jul 2021];19:71. Disponible en: https://link.springer.com/article/10.1186/s13075-017-1276-2
Wu X, He B, Liu J, Feng H, Ma Y, Li D, et al. Molecular insight into gut microbiota and rheumatoid arthritis. Int J Mol Sci [Internet]. 2016 [citado 12 Jul 2021];17(3):431. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813281/
Chen J, Wright K, Davis JM, Jeraldo P, Marietta EV, Murray J, et al. An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Genome Med [Internet]. 2016 [citado 12 Jul 2021];8:43. Disponible en: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0299-7
Gan RW, Bemis EA, Demoruelle AK, Striebich CC, Brake S, Feser ML, et al. The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population. Rheumatology [Internet]. 2017 [citado 12 Jul 2021];56(12):2229-36. Disponible en: https://academic.oup.com/rheumatology/article/56/12/2229/4344763?login=true
Hu Y, Sparks JA, Malspeis S, Costenbader KH, Hu FB, Karlson EW, et al. Long-term dietary quality and risk of developing rheumatoid arthritis in women. Ann Rheum Dis [Internet]. 2017 [citado 12 Jul 2021];76(8):1357-64. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556680/
Pianta A, Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, et al. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest [Internet]. 2017 [citado 12 Jul 2021];127(8):2946-56. Disponible en: https://www.jci.org/articles/view/93450
Edwards JC. The nature and origins of synovium: experimental approaches to the study of synoviocyte differentiation. J Anat [Internet]. 1994 [citado 12 Jul 2021];184(Pt3):493-501. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1259957/
Sergijenko A, Roelofs AJ, Riemen AH, De Bari C. Bone marrow contribution to synovial hyperplasia following joint surface injury. Arthritis Res Ther [Internet]. 2016 [citado 12 Jul 2021];18:166. Disponible en: https://link.springer.com/article/10.1186/s13075-016-1060-8
Sabeh F, Fox D, Weiss SJ. Membrane-type I matrix metalloproteinasedependent regulation of rheumatoid arthritis synoviocyte function. J Immunol [Internet]. 2010 [citado 12 Jul 2021];184(11):6396-406. Disponible en: https://www.jimmunol.org/content/184/11/6396.short
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. [Internet]. 2011 [citado 12 Jul 2021];365:2205-19. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMra1004965
Pap T, Korb-Pap A. Cartilage damage in osteoarthritis and rheumatoid arthritis--two unequal siblings. Nat Rev Rheumatol [Internet]. 2015 [citado 12 Jul 2021];11(10):606-15. Disponible en: https://go.gale.com/ps/i.do?id=GALE%7CA430548702&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=17594790&p=AONE&sw=w&userGroupName=anon%7E4a90fcd6
Arts EE, Fransen J, Den Broeder AA, van Riel P, Popa CD. Low disease activity (DAS28=3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent Cox regression analysis in a large cohort study. Ann Rheum Dis [Internet]. 2017 [citado 12 Jul 2021];76(10):1693-9. Disponible en: https://ard.bmj.com/content/76/10/1693.abstract
Myasoedova E, Crowson CS, Kremers HM, Fitz-Gibbon PD, Therneau TM, Gabriel SE. Total cholesterol and LDL levels decrease before rheumatoid arthritis. Ann Rheum Dis [Internet]. 2010 [citado 12 Jul 2021];69(7):1310-4. Disponible en: https://ard.bmj.com/content/69/7/1310.short
Chen YJ, Chang YT, Wang CB, Wu CY. The risk of cancer in patients with rheumatoid arthritis: a nationwide cohort study in Taiwan. Arthritis Rheum [Internet]. 2011 [citado 12 Jul 2021];63(2):352-8. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/art.30134
Deane KD. Can rheumatoid arthritis be prevented? Best Pract Res Clin Rheumatol [Internet]. 2013 [citado 12 Jul 2021];27(4):467-85. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1521694213000661
Finckh A, Liang MH, van Herckenrode CM, de Pablo P. Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: a metaanalysis. Arthritis Rheum [Internet]. 2006 [citado 12 Jul 2021];55(6):864-72. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/art.22353
Fuchs HA, Kaye JJ, Callahan LF, Nance EP, Pincus T. Evidence of significant radiographic damage in rheumatoid arthritis within the first 2 years of disease. J Rheumatol. 1989 [citado 12 Jul 2021];16(5):585-91. Disponible en: https://europepmc.org/article/med/2754663
Naldini L. Gene therapy returns to centre stage. Nature [Internet]. 2015 [citado 12 Jul 2021];526:351-60. Disponible en: https://www.nature.com/articles/nature15818
Kim MJ, Park JS, Lee SJ, Jang J, Park JS, Back SH, et al. Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy. J Control Release [Internet]. 2015 [citado 12 Jul 2021];216:140-8. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0168365915300705
Lee SJ, Lee A, Hwang SR, Park JS, Jang J, Huh MS, et al. TNF-alpha gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis. Mol Ther [Internet]. 2014 [citado 12 Jul 2021];22(2):397-408. Disponible en: https://www.sciencedirect.com/science/article/pii/S1525001616311613
Lundstrom SL, Hensvold AH, Rutishauser D, Klareskog L, Ytterberg AJ, Zubarev R, et al. IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis. Arthritis Res Ther [Internet]. 2017 [citado 12 Jul 2021];19:182. Disponible en: https://link.springer.com/article/10.1186/s13075-017-1389-7
Whang JA, Chang BY. Bruton’s tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. Drug Discov Today [Internet]. 2014 [citado 12 Jul 2021];19(8):1200-04. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1359644614001226
Alvaro-Gracia JM, Jover JA, García-Vicuña R, Carreño L, Alonso A, Marsal S, et al. Intravenous administration of expanded allogeneic adipose- derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Ann Rheum Dis [Internet]. 2017 [citado 12 Jul 2021];76(1):196-202. Disponible en: https://ard.bmj.com/content/76/1/196.short
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