Clinical, electro and telecardiographic manifestations in a series of patients with systemic sclerosis
Keywords:
systemic sclerosis, heart condition, exertional dyspneaAbstract
Introduction: Systemic sclerosis is a chronic connective tissue disease characterized by vascular dysfunction and microvascular alterations that lead to ischemia and fibrosis of tissues and organs, including the cardiovascular system.
Objective: To characterize the cardiac manifestations from the clinical, electro and telecardiographic point of view in patients with systemic sclerosis.
Methods: A descriptive, cross-sectional study was carried out in patients from the Reference Center for Rheumatic Diseases, from January 2018 to march 2020. Sociodemographic, clinical, electrocardiographic and radiological variables were analyzed. Chi-square and Fisher's exact tests were used to identify association; Linear trend was used in the variable time of diagnosis.
Results: The diffuse form was present in 69,6 %; there were 28,2 % of patients between 50 and 59 years of age. The female sex was 92,95 %, those with non-white skin 57,6 % and with more than 10 years of diagnosis there was 36,6 %. Dyspnea on exertion was the most frequent symptom with 68,2 %. Heart murmur was evidenced in 18,8 %. Ventricular hypertrophy was observed in 31,8 % of cases.
Conclusions: The frequency of cardiovascular pain was significant; exertional dyspnea was the most frequent symptom described by the patients and heart murmur, the most identified finding in the physical examination.
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References
-Iglesias A. Historia de la esclerodermia. Rev. Medicina [Internet]. 2015 [citado 7 May 2019];37(4):[aprox. 5 p.]. Disponible en: https://revistamedicina.net/ojsanm/index.php/Medicina/article/dowload/111-10/954/
-Rubio Rivas M, Moreno R, Corbella X. Occupational and environmental scleroderma. Systematic review and metaanalysis. Clin Rheumatol [Internet]. 2017 [citado 7 May 2019];36(3):[aprox. 4 p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28091808/
-Carreira PE, López M, Pablos JL .Esclerodermia. Medicine [Internet]. 2017 [citado 7 May 2019];12(25):[aprox. 5 p.]. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=5826912
-Vázquez Doval FJ. La esclerodermia. Paso a paso [Internet]. 2017 [citado 7 May 2019];7(2): [aprox. 5 p.]. Disponible en: https://www.esclerodermia.es/img/revista7.pdf
-Bellando S, Guiducci S, Cappelli S, Bruni S, Matucci M. Esclerosis Sistémica. En: Enfermedades inflamatorias reumatológicas. Producciones científicas Ltda; 2016. p. 397-447.
-Gottschalk P, Vásquez R, López PD, Then J, Tineo C, Loyo E. Esclerodermia en el Caribe: características en una serie de casos dominicana. Reumatol Clin [Internet]. 2014 [citado 18 Ene 2019];10(6):373-9. Disponible en: https://www.reumatologiaclinica.org/es-esclerodermia-el-caribe-caracteristicas-una-articulo-S1699258X14000448
-Reyes Llerena GA, Guibert Toledano ZM, López Cabreja G, Hernández Derivet C, Álvarez Rubén M, Martínez Larrarte JP, et al. Evaluación clínico epidemiológica de una serie de casos en dos centros de referencia en Cuba. Rev Cubana Reumatol [Internet]. 2014 [citado 15 Nov 2018];16(Supl.1):346-55. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-59962014000400002&lng=es
-Remedios S, Montada E, Rivas R. Caracterización clínica epidemiológica de pacientes con esclerosis sistémica en Holguín. Rev Cubana Reumatol [Internet]. 2017 [citado 15 Nov 2018];20(1):[aprox. 5 p.]. Disponible en: http://www.revreumatologia.sld.cu/index.php/reumatologia/article/view/592
-Rodríguez JF, Yglesias Jl, Dueñas M, Díaz M. Esclerosis Sistémica Progresiva. Aspectos clínicos epidemiológicos en la provincia de Pinar del Rio. Rev Cubana Reumatol [Internet]. 2000 [citado 15 Nov 2018];2(1):[aprox. 5 p.]. Disponible en: http://revreumatologia.sld.cu/index.php/reumatologia/article/view/172/192
-Amoda O, Ravat V, Datta S, Saroha B, Patel RS. Trends in Demographics, Hospitalization Outcomes, Comorbidities, and Mortality Risk among Systemic Sclerosis Patients. Cureus [Internet]. 2017 [citado 15 Nov 2018];10(5):[aprox. 5 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044481/
-Alegre JJ, Fernández Matilla M, Feced Olmos C, Valls Pascual E, Martínez Ferrer A, Ybáñez García D. Esclerosis sistémica. En: Enfermedades reumáticas. Actualización SVR. Valencia: Ibañez & Plaza asociados s.l; 2013. p. 265-304.
-Barrera A, Campaña A, Jardines G, Peralta R, Sánchez S, Yáñez P, et al. Evidencias y manifestaciones. En: Diagnóstico, Tratamiento y Pronóstico de la Esclerosis Sistémica. México D.F.: Ed CENETEC; 2010. p. 12-57. [Internet] [citado 15 Nov 2018]. Disponible en: http://www.cenetec.salud.gob.mx/interior/gpc.html
-Rubio Rivas M. Cambios en el patrón de mortalidad de la cohorte del registro español de esclerodermia [tesis]. Barcelona: Universidad Autónoma de Barcelona; 2014. [Internet] [citado 19 Ene 2019]. Disponible en: https://core.ac.uk/download/pdf/78531126.pdf
-Follansbee WP, Curtiss EI, Rahko PS, Medsger TA, Lavine SJ, Owens GR, et al: The electrocardiogram in systemic sclerosis (scleroderma): Study of 102 consecutive cases with functional correlations and review of the literature. Am J Med [Internet]. 1985 [citado 15 Nov 2018];79(2):183-91. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/0002934385900087
-Bennasar G, Carlevaris L, Secco A, Romanini F, Mamani M. Trasplante cardíaco en una paciente joven con diagnóstico de esclerosis sistémica difusa. Reumatol Clinic [Internet]. 2016 [citado 15 Nov 2018];12(5):285-7. Disponible en: https://www.sciencedirect.com/science/article/pii/S1699258X15001588
-Centro de documentación de Bioética. Departamento de Humanidades Biomédicas. Universidad de Navarra. Declaración de Helsinki de la AMM - Principios éticos para las investigaciones médicas en seres humanos; 2013. [Internet] [citado 11 Nov 2020];1-5. Disponible en: http://www.redsamid.net/archivos/201606/2013-declaracion-helsinki-brasil.pdf?1
-Lara ME, Rivero MA, Zazzetti F, Khoury MC, Laborde HA, Barreira JC. Frecuencia de úlceras digitales en esclerodermia. Rev Arg Reumatol [Internet]. 2016 [citado 15 Nov 2018];27(2):11-4. Disponible en: http://revistasar.org.ar/revistas/2016/n2/2_articulo_original.pdf
-Mouthon L, Rannou F, Bérezné A, Pagnoux C, Aréne J-P, Foïs E, at al. Development and validation of a scale for mouth handicap in systemic sclerosis: the Mouth Handicap in Systemic Sclerosis. Ann Rheum Dis [Internet]. 2007 [citado 11 Nov 2020];66(12):1651-5. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095324/
-Scolnik M, Lancioni E, Catoggio LJ, Sabelli M, Bedrán Z, Saucedo C, et al. Pronóstico en Esclerosis Sistémica: ¿Subtipos clínicos o autoanticuerpos? [Internet]. Argentina: Hospital Italiano; 2014. [Internet] [citado 11 Nov 2020];[aprox. 6 p.]. Disponible en: https://www.hospitalitaliano.org.ar/multimedia/archivos/servicios_attachs/8045.pdf
-Silvariño R, Rebella M, Alonso J, Cairoli E. Manifestaciones clínicas en pacientes con esclerosis sistémica; Rev Med Urug [Internet]. 2009 [citado 11 Nov 2020];25(2):84-91.[aprox. 6 p.]Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-03902009000200003&lng=es
-Gallardo A, Calebotta A, Ruiz A. Esclerodermia: influencia del engrosamiento cutáneo en la calidad de vida? Venezuela: Hospital Universitario de Caracas: Simón Bolivar; 2016. [Internet] [citado 11 Nov 2020];[aprox. 6 p.]. Disponible en: http://190.169.30.62/handle/10872/16345
-Silveira-Torre LH. Afección cardíaca en la esclerosis sistémica. Reumatol Clin [Internet]. 2006 [citado 11 Nov 2020];2(Supl.3):S31-6. Disponible en: https://www.sciencedirect.com/science/article/pii/S1699258X06731059
-Morales Villeda J, Olivera P, Cruz P. Manifestaciones cardiopulmonares de esclerosis sistémica sin esclerodermia y avances en el tratamiento. Reporte de un caso. Rev Med Hondur [Internet]. 2017 [citado 11 Nov 2020];85(1y2):30-4. Disponible en: https://revistamedicahondurena.hn/assets/Uploads/Vol85-1-2-2017-8.pdf
-Vázquez Fuentes N, Querol Gutiérrez JJ, Miralles Ibarra JM, Merino de Torre R, Querol Gutiérrez JC, Laza Laza E. Afectación cardíaca de la esclerosis sistémica. Un caso de taquicardia de QRS ancho. Unidad de Reumatología. Hospital de Ceuta. España. Emergencias [Internet]. 2008 [citado 11 Nov 2020];20(4):285-8. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/ibc-66666
-Grosso O, Saad AK, Volberg VI, Bresan E, Laborde H, Berensztein CS, et al. El ecocardiograma en la esclerodermia. Insuf Card [Internet]. 2011 Sep [citado 11 Nov 2020];6(3):106-11. Disponible en: https://www.redalyc.org/pdf/3219/321927795002.pdf
-García de la Peña Lefebvre P. Esclerodermia localizada. Servicios Universitarios del grupo Madrid. Protoc Diagn Ter Pediatr [Internet]. 2014 [citado 11 Nov 2020];1:101-6. Disponible en: https://nanopdf.com/download/esclerodermia-localizada-asociacion-espaola-de-pediatria_pdf
-Porras Antras I, León Guisado A, Sotomayor de la Piedra C, Montero Mateo E, González León R, López Pardo F, et al. Alteraciones ecocardiográficas en pacientes con Esclerodermia. Rev Española Cardiol [Internet]. 2013 [citado 11 Nov 2020];213(Espec Congr):627. Disponible en: https://www.revespcardiol.org/en-congresos-xxxiv-congreso-nacional-sociedad-espanola-8-sesion-inflamacion-enfermedades-autoinmunes-posters--845-alteraciones-ecocardiograficas-en-pacientes-con-8175-pdf
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